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Diazepam is the generic name, and active ingredient in the branded Valium tablet. Valium 10 mg is a benzodiazepine medication that was approved by the Food and Drug Administration (FDA) in 1963. It is often prescribed to people who are experiencing severe symptoms of anxiety or as a sleeping pill for people that are having trouble sleeping. It is now conveniently available here, without the need for a prescription.
The History of Diazepam
Benzodiazepines are a class of medications which have a core chemical structure of a benzene ring fused to a diazepine ring. These psychoactive medicines have gained popularity since its discovery in 1955. As per the New England Journal of Medicine, the number of benzodiazepine users has increased from eight to almost 14 million in the period of 1996 to 2013.
The first benzodiazepine to be discovered was named chlordiazepoxide (Librium). This discovery was made by the organic chemist, Leo Sternbach of the Swiss healthcare company, Hoffmann-La Roche. Following this discovery, the successor to Librium was found in the form of diazepam. It became the highest selling medication in the United States between 1968 and 1982. More than two billion tablets were sold in the year 1978 alone.
Much of the popularity of benzodiazepines was due to these medications having a safer pharmacological profile over the current therapeutics of those times, barbiturates. Barbiturates act on the central nervous system, much like benzodiazepines, but this class of prescription tablets is highly addictive and considered less safe.
Benzodiazepines were considered an improvement over barbiturates because of the narrow therapeutic index of the predecessor. The therapeutic index is a measure of the safety of a pharmaceutical. Unless consumed in very large quantities, benzodiazepines were thought to be far less dangerous than barbiturates. It then became easy to find diazepam for sale as benzodiazepines were much more popular than barbiturates.
Fast forward to current times and the popularity of this medication remains, with five million prescriptions for diazepam recorded in 2017 solely. Considering how easy it is to buy diazepam online, it is understandable that this therapeutic is still a popular choice.
What is Diazepam Used For?
The diazepam tablet can be used for a variety of conditions including the short term relief of severe anxiety that is disabling or causing a person to experience intolerable distress. It is often used to help manage the symptoms of anxiety disorders such as generalised anxiety disorder (GAD), panic disorder and obsessive compulsive disorder (OCD).
Diazepam 10 mg tablets are also used to manage insomnia which is characterised by difficulty falling asleep, staying asleep or waking up too early. It can help relieve muscle spasms and treat the symptoms of alcohol withdrawal. It is also used to help relax nervous patients before undergoing an endoscopic or dental procedure. It can be helpful as a preoperative sedative before a minor surgery. It is also sometimes used in combination with other medications to treat seizures.
Diazepam Side Effects
Like all medications, diazepam 10 mg tablets have potential side effects although most people are not affected by them. A few of the more common side effects may include:
Less common diazepam side effects could include:
- Difficulty concentrating
- Memory issues
Diazepam Usage Instructions
- If you take this medication for anxiety, the recommended adult dose is 5mg to 30mg each day in divided doses.
- If you use it to help you sleep, the recommended adult dose is 5 mg to 15 mg at bedtime (10 mg is the most commonly used dosage for relief from insomnia).
- To help control muscle spasms, take 5mg to 15mg each day in divided doses.
- If you buy diazepam online and use it for alcohol withdrawal, take 5 mg to 20 mg which may be repeated every 2 – 4 hours.
- To help relax you before a medical procedure take between 5 mg and 20 mg.
*This is a basic guide, your individual dosage can be influenced by many factors including your health status, present treatments and more. Research further and consult a doctor if necessary.
Diazepam for Sleep & Anxiety
This medication is used for its tranquilising and muscle-relaxing effects. It causes the release of gamma-Aminobutyric acid (GABA) which is a neurotransmitter in the brain. GABA is made naturally in the brain and it acts as a calming messenger that helps keep nerve activity balanced. It plays an important role in causing sleep, relaxing muscles and reducing anxiety.
Diazepam for anxiety
Anxiety, although being a normal emotional response, can become disabling if the individual feels distressed in an usual proportionality to normal emotions. It was estimated in 2017 that around 4% of the worldwide population had an anxiety disorder. When you feel anxious, an effective diazepam dosage can help create a sense of calm and relaxation by increasing the levels of the chemicals responsible for these feelings.
Diazepam for insomnia and other sleep disorders
There are four major types of sleep disorders:
- Sleep apnea
- Restless legs syndrome
- REM sleep behavior disorder
Insomnia is the most common type of sleep disorder. It is known to disrupt the lives of 10% of the adult population chronically and as an acute ailment, is known to affect 25% of adults. Insomnia can be regarded as chronic if it occurs for at least three nights per week, for three months or longer. It is not only a disruption to one’s life physically but can be detrimental both emotionally and mentally as well.
Using Valium for sleep can be suitable for the treatment of insomnia and other sleep disturbances. This off-label benefit of diazepam 10 mg is brought about when the active ingredient increases the efficiency of a natural chemical found in the brain. This chemical GABA (gamma-amino butyric acid) is a neurotransmitter and decreases the excitability of the neurons. Consequently, there is a reduction in the communication between neurons and hence, a calming effect occurs on many functions of the brain.
Valium 10 mg is sufficient to induce sleep onset, reduce the number of nightly awakenings and increase total sleep time. If required for sleep, you can find diazepam for sale on our reputable website.
Diazepam as a muscle relaxant
Muscle relaxants function by decreasing muscle tone and influencing skeletal muscle function. It assists in the management of symptoms of muscle pain and spasms. Whilst some are prone to muscle spasms, physical exertion, stress and dehydration can be frequent causes for tender and painful muscles.
Infants, endurance athletes, senior citizens and chronically ill individuals are commonly affected by muscle spasms. Relaxing muscles or reducing the pain associated with the ailment is one of the more common Valium effects, especially for those with multiple sclerosis and other disorders.
Diazepam works on the brain and spinal cord (central nervous system) to cause muscles to become less tense which in turn, relieves the pain associated with these stiff muscles. It is therefore customary to find diazepam for sale as muscle relaxants, in addition to being used for anxiety.
Using a diazepam tablet in situations of over-exercising can provide relief to sore or stiff muscles. For more localized relief, there are diazepam preparations which can be injected directly into the affected area.
Diazepam for Alcohol Withdrawal
Alcohol withdrawal syndrome (AWS) is the effects the body takes after using alcohol for a long period of time. These symptoms of withdrawal can range from headaches to fever and intense agitation. It is estimated that 50% of people who have an alcohol addiction will experience withdrawal symptoms of some sort and 3 to 5% will be affected by the symptoms of this syndrome.
Alcohol withdrawal is common but delirium tremens is a fatal form of this condition. It occurs in 5% of people who have used alcohol for an excessive period and are in withdrawal. One of the characteristics of delirium tremens is intense agitation.
Intense agitation can be controlled by diazepam as sedation is one of the most well-known Valium effects. A diazepam dosage may be effective in the management of these symptoms as this medication has a rapid distribution in the body and therefore can assist quickly with symptoms of agitation. Other than its swift distribution, this benzodiazepine also has high lipid solubility and a relatively long duration of action.
Diazepam and alcohol should never be use together as they are both depressants of the nervous system and can have negative implications on the body.
Diazepam as Premedication
Other than using Valium for sleep, it can be used for sedation. The sedative effects of diazepam were investigated by Khosla and Boren (1969) in comparison to meperidine (a narcotic analgesic similar to morphine) – promethazine (antiemetic). They found that when using intravenous diazepam 10 mg as a premedication for patients undergoing oral surgery under local anesthesia, there were hardly any diazepam side effects. Furthermore, the onset of action was quick (within minutes) and the effects of the medication disappeared at the end of the procedure (at the end of 40 minutes). When compared to the alternative in the trial, diazepam was found to be superior as the effects of meperidine – promethazine lasted at least one and a half hours longer than required.
This medication has been popular as a sedative and anxiolytic prior to surgical procedures as it is rapidly absorbed when taken by mouth or intravenously, causes anterograde amnesia and does not result in emetic side effects. It works by influencing the nerve communications from the central nervous system to the brain which slows down brain activity. This therefore relaxes the body and sedates one before a medical procedure.
Diazepam for seizures
Seizures are defined as uncontrolled activity between nerve cells and result in different abnormalities such as twitching or limpness. Epilepsy is a condition which causes a person to experience these seizures.
They are common in young children but can also be seen in older individuals. Approximately one in every 100 persons has experienced a seizure or been diagnosed with epilepsy in the United States (U.S) and one in every 26 people will experience this in their lifetime.
With such high statistics, a fast-acting and effective treatment is required. Intravenous diazepam is a first-line treatment for patients of status epilepticus. In 2020, the nasal spray version of this medication was approved for use to reduce seizure disruptions in those with epilepsy. It is also used for children (under the age of five years) for the prevention of febrile seizures because the recurrence rates are low and there have been few diazepam side effects noted.
Other Valium effects include using the medication in emergency situations for those who have eclampsia, a condition where women with pre-eclampsia (a disorder of hypertension in pregnant women) experience convulsions or seizures. This route of treatment is for situations where magnesium sulfate intravenous treatments and measures to control blood pressure levels have failed.
Diazepam Dosage Guide
- Take diazepam 10 mg tablets whole with some water just before going to sleep.
- If you are elderly or have liver or kidney problems, the dose should not be more than half the adult dose.
- If you forget to take a dose, do not take a double dose to make up for a forgotten dose.
- Diazepam and alcohol should not be taken together.
- Only buy Valium if you are not taking monoamine oxidase inhibitors (MAOIs) which are medications used to treat depression.
- Other medications used for anxiety such as alprazolam or clonazepam should not be taken at the same time as a diazepam tablet.
Diazepam for Sale Online
- If you buy diazepam online use this medication with caution if you have problems with your heart or lungs or have severe kidney problems.
- Use this medication with caution if you have low blood levels of a protein called albumin.
- Use this medication with caution if you are elderly as it can have effects on muscles and coordination.
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